Testosterone Therapy: What Men Need to Know About Low T and TRT Treatment Los Angeles Times
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Testosterone is a hormone present in all women that declines with age and it has effects on muscle; therefore, it was hypothesized that it would augment the benefits of exercise during the recovery period. Spatial transcriptomics enables precise mapping of immune cell locations and gene activity in prostate tissue, revealing how T cells, including tissue-resident memory CD8+ T cells, respond to changes in testosterone levels. Understanding these interactions may inform improved immunotherapies for prostate cancer and other hormone-influenced conditions. While most studies on testosterone and body composition have focused on men, particularly in populations with spinal cord injury (SCI), some emerging evidence supports similar benefits in women. As we enter older adulthood, understanding testosterone levels becomes increasingly important for overall health and well-being.
This is a new kind of cartography, a mission that may guide us toward better medicine for all. Now Dr. Reina-Campos is investigating how specialized "tissue-resident memory CD8+ T cells" fight prostate cancer. Already, Dr. Reina-Campos has shown the power of spatial transcriptomics in studying T cells that fight pathogens in the gut. He has also developed a promising approach for powering up T cells to better fight tumors. "Spatial transcriptomics enables us to look at hundreds of thousands of cells and thousands of genes in prostate tissues." By tracking this immune-cell activity, Dr. Reina-Campos can help guide the development of new immunotherapies for prostate cancer, a disease that kills around 35,700 men each year. LJI Assistant Professor Miguel Reina-Campos, Ph.D., specializes in using spatial transcriptomics tools to advance the field of tissue immunology.
As T levels decline, so do sperm counts and semen quality, which can lead to issues in fertility, he says. For those who want to grow their family, this can lead to high levels of emotional stress on the individual and family levels. "On a societal scale, this could exacerbate population challenges, particularly in countries already experiencing aging populations and workforce shortages," he says. The most prominent is a 2007 study published in the Journal of Clinical Endocrinology & Metabolism, which found that men in the 2000s had "substantially" lower testosterone levels compared to men of the same age in the 1980s and 1990s. The decline was observed across all age groups, but researchers said it raised particular concerns regarding younger populations. The normal range for free testosterone can vary based on factors such as age, health status, and laboratory testing methods.
While we work with many popular labs, we welcome reports from lots of other places too. In addition, certain conditions are known to affect free testosterone like hyperthyroidism and some types of kidney disease. That’s why high T-levels in women are considered to be more dangerous than the equivalent condition in men. Spironolactone is one of the most effective medications for women with high T. Free testosterone isn’t bound to anything, so it’s free to get into cells and get to work. Most of the testosterone in your body is what’s called "bound," explains family physician Nick Dahl, D.O., who treats men with low testosterone (hypogonadism). Your doctor might order it if you have symptoms of low or high testosterone.
Free T is not bound to albumin or sex hormone-binding globulin and plays an essential role in muscle growth, sex drive, and mood stability [4]. For instance, a 2021 study in Infection found that among HIV-positive men (for whom low T is very common), only 10.6 percent met diagnosis for hypogonadism based solely on total testosterone levels. But when considering calculated free testosterone, luteinizing hormones, and sex hormone-binding globulin levels, up to 20.2 percent of men would qualify as having subsets of the condition, like overt or compensated hypogonadism. In males aged 19 to 39 years, the harmonized normal range of total testosterone is 264 to 916 ng/dL47, with age-specific median levels ranging from 409 to 478 ng/dL in those aged 20 to 44 years48.
After the initial assessment, the participants were randomly divided into 2 groups using a random table generator. The control group was advised to walk for 30 min three times a week on alternate days for 16 weeks along with a standard dietary plan. In this protocol, different types of exercises, resistance, endurance, and balance, were integrated with proper warm-ups, cool-downs, and rest intervals, which required minimal setup (with only handheld dumbbells), as shown in Table 1.
Leading a sedentary lifestyle may exacerbate testosterone declines in men as they age, according to a 2024 review published in Frontiers in Aging. But on the flip side, "regular physical activity, including strength training, has been linked to supporting healthy testosterone levels," according to Bailey. Exposure to certain environmental toxins and endocrine disruptors, like bisphenol A (BPA), pesticides, and phthalates, can impact hormone levels, including testosterone.
Treatment focuses on identifying and addressing the underlying cause, such as discontinuing steroid use or treating underlying medical conditions. Lifestyle adjustments, including a balanced diet and regular exercise, are important, and medications may be prescribed to regulate hormone levels in certain cases. Regular medical monitoring is essential to track testosterone levels and modify treatment as needed. Psychological counseling can also be beneficial, especially if mood swings or aggression are present. Overall, managing elevated testosterone auto injector (https://www.ihromamz.it/pages/dianabol_acquisto_1.html) requires a comprehensive, medically supervised approach, considering the individual's health and the specific reasons behind the hormonal imbalance.
Comparing results to age-specific reference ranges allows for a better understanding of hormonal balance and potential underlying issues. Whether it's addressing symptoms, monitoring hormone replacement therapy, or assessing general health, testing testosterone levels provides valuable information to guide personalized care and optimize overall well-being. Although women have lower testosterone concentrations, this hormone remains critical for various physiological functions, including muscle development, bone density maintenance, and overall metabolic health50(Clark et al., 2018). Resistance exercise has been shown to induce acute increases in testosterone levels in both sexes, potentially contributing to improved musculoskeletal adaptations over time46.
